Slampyak was born in Philadelphia and is a 1987 graduate of Temple University's Tyler School of Art. He is the creator of Jazz Age Chronicles, which was originally published for two years by EF Graphics and Caliber Comics, and is now a webcomic. During the 1990s, he worked as an artist on, among other things, Neil Gaiman's Mr. Hero from Tekno Comix. He also contributed to Paradox Press' The Big book of... titles and created mini-comics featuring his libertarian heroine Suzi Romaine. He drew on the syndicated comic strip Little Orphan Annie, until it was canceled on June 13, 2010. His work has been nominated for an Ignatz Award, and he has been the recipient of a local Addy Award by the American Advertising Federation.